Don't bluff fishes and stations
Generally a low Fold to Flop Cbet and high Fold to Turn Cbet is a good time to 2barrel lighter.
River bluffs are pretty hard to get right, because often you get some wtf crying calls even from non stations because there's often so much money in the pot. The thing with river bluffs in my opinion is to only do them when your opponents range is very narrow and a disaster card for their range hits the river, and you can conceivably have it in your range. For bluffing regs, Look at your own game for spots where cards hit that make you wanna puke. Because when the situation is reversed, these are the spots to bluff back at your opponents.
accidentally quoted myself instead of editing post