Lately, in order to get action on more tables, I have been opening new tables quite a lot and that is why I find myself in heads-up or short-handed situations until table fills up. I see this as good practice for SH tables, so no problem there, but...
I have one question:
Is it profitable in general to play against $5 shortie heads-up if I have full $25 stack?
And what to do in following scenarios:
1) shortie is unknown
2) shortie is a well known regular, who follows very good SS
3) shortie is a well known fish
4) we have multiple (2-3) shorties
What about midstacks?
I suspect that it is not profitable unless I know 100% that he will reload when busted and even then I doubt it... I would really appreciate detailed answers from people who know, thank you! 
p.s. if there is some kind of guide or discussion about this already I would appreciate if someone would provide a link.
