Adjusting to non pot size opens

I would say that from MP, CO and BTN I wouldn't change a lot. For calling price gets better, but also there will be more often multiway pots (as the price is better for everyone). If we widen the range significantly, we find ourselves in multiway pots with crappy hands often.

From SB and BB things change. We shouldn't increase our 3betting range, but we should widen our calling range, especially from BB.

Also one adjustment I often make is to give little more weight for that player to be Holdem player. Anyone who has played and studied PLO more should use pot size preflop. So overall someone using 2,5x is more likely a Holdem player.

compared midstakes sim 2,5x vs pot open, bb changes a lot as said.
the sb doubles up the calling freq vs late as well, but as the number still is pretty low >10%, the adjustments on low stakes with higher rake might be pretty minor.