Just a case of pokerstoving his ranges against 22 and see if you can call. Your calling 4 to win 6 so you are getting 3:2 so i guess that means you need to have 40% equity against his range.
equity win tie pots won pots tied
Hand 0: 39.969% 39.60% 00.37% 107132660 1000971.00 { 2c2d }
Hand 1: 60.031% 59.66% 00.37% 161409430 1000971.00 { 66+, A8s+, KJs+, A9o+, KQo }
range is taken from http://www.pokerstrategy.com/strategy/no-limit/207/2/ and assuming you have a 30% attempt to steal and he plays "perfectly". So it looks like you are right on the cusp and is probably neutral EV.