Really depends on how wide he is calling on the flop, and how wide he is calling on the river. If you had reads to go for it, then yeah. Readless I would not do it.
In order to valuebet the river, you need to beat over 50% of his calling range.
If he calls with 40% prelop, and 45+ on the flop, he has 2/3 of his river range flushes and 1/3 2 pairs or sets. So you can't valuebet. This is assuming he would just call on the flop with nut flush and check it on the river.
If we assume that he can't have nut flush there on the river, he still has a bit more flushes than 2pair/set in his range. Can't valuebet.
If we give him wider flop range (23+,45+,Q) he still has more flushes than 2pair/set. And he starts to have some JT in his range too.
With wide flop range and removal of nut flush from his range, the scale finally barely turns to him having more weaker hands in his river calling range. Assuming he is calling your bet even with 54xx.
To make your river bet profitable, there's a long list of "if's" that need to happen. And even in the best case scenario it's marginally profitable.
Easy check on the river.