Good example of vacuum vs long run strategy.
If we would play only this hand in our life, our strategy would be probably a bit different. But in our long run strategy, we should be thinking about our leading range. How often we want to lead, and then figure out how to construct that range.
If we play poker in a way where we lead "something" and "sometimes", we really don't have a strategy. We have just decisions based on feelings, not logic. What we should do, is to think first how balanced our leading range should be. And then come up with value range and bluffing range. Of course we would need to think about turn/river situations too, how often we can barrel with certain hands.
Solver leads this kind of board about 1/4 times, and very rarely without a diamond of either hit or straight blockers. In reality people at PLO25 over cbet in 3bet pots, even on these boards. And on the other hand, they under fold to single donks. So if you want to bluff the flop, you should barrel blank turns at least. Here the stack sizes are a bit short, as you would have SPR 1 on the turn. If he calls the flop and he has something, he probably calls turn often too. People in general are really bad in equities and pot odds.
What my experience in PLO25 and lower is, people stack off in 3bet pots WAY too wide. Therefore bluffing has a lot less value than in solver calculations. I have seen so often people shoving dry AA here or making a call down. Personally I wouldn't bluff/semibluff here without Ad in my hand.